Table 8 The relationship between NLRP3 genotypes and serum concentrations of NLRP3, IL-1β, and IL-18 levels in CC
SNP | Index | Â | Genotype | Â | Â | P value |
|---|---|---|---|---|---|---|
rs10754558 |  | CC(n = 74) | CG(n = 122) | GG(n = 31) |  |  |
| Â | NLRP3(pg/ml) | 1378.9(778.9,2851.1) | 1417.8(828.9,2641.4) | 2281.7(917.8,3738.6) | CCvs.CG | 0.778 |
| Â | Â | Â | Â | Â | CCvs.GG | 0.158 |
|  | IL-1β (pg/ml) | 50.3(31.2,83.3) | 58.8(43.0,88.9) | 85.0(46.0,104.0) | CCvs.CG | 0.074 |
| Â | Â | Â | Â | Â | CCvs.GG | 0.014 |
| Â | IL-18(ng/L) | 139.9(86.9,257.1) | 149.9(115.0,235.9) | 239.8(132.3,308.5) | CCvs.CG | 0.461 |
| Â | Â | Â | Â | Â | CCvs.GG | 0.032 |
rs10733113 |  | GG (n = 159) | GA (n = 56) | AA (n = 12) |  |  |
| Â | NLRP3(pg/ml) | 1462.2(834.4,3092.8) | 1290.0(734.4,2434.4) | 2506.7(842.8,3923.3) | GGvs.GA | 0.513 |
| Â | Â | Â | Â | Â | GGvs.AA | 0.461 |
|  | IL-1β (pg/ml) | 55.4(35.4, 90.6) | 61.6(50.1,86.6) | 71.9(30.1,106.9) | GGvs.GA | 0.191 |
| Â | Â | Â | Â | Â | GGvs.AA | 0.692 |
| Â | IL-18(ng/L) | 151.5(103.8,251.9) | 161.7(121.9,250.3) | 240.4(97.4,328.8) | GGvs.GA | 0.451 |
| Â | Â | Â | Â | Â | GGvs.AA | 0.413 |