Table 6 Associations between NLRP3 polymorphisms and CC patient pathological characteristics
SNP | Pathological parameters | Genotype | Â | P value | OR (95%CI) | ||
|---|---|---|---|---|---|---|---|
rs10754558 | Â | CC n(%) | CG n(%) | GG n(%) | Â | Â | Â |
| Â | Pathological types | Â | Â | Â | Â | Â | Â |
|  | Squamous carcinoma(n = 171) | 55(32.16) | 93(54.39) | 23(13.45) | CCvs.CG | 0.764 | 0.903(0.463–1.760) |
|  | Adenocarcinoma(n = 56) | 19(33.93) | 29(51.78) | 8(14.29) | CCvs.GG | 0.989 | 1.007(0.386–2.626) |
| Â | TNM stage | Â | Â | Â | Â | Â | Â |
|  | I/II(n = 143) | 50(34.96) | 76(53.15) | 17(11.89) | CCvs.CG | 0.455 | 1.261(0.686–2.319) |
|  | III/IV(n = 84) | 24(28.57) | 46(54.76) | 14(16.67) | CCvs.GG | 0.216 | 1.716(0.727–4.049) |
| Â | Differentiated degree | Â | Â | Â | Â | Â | Â |
|  | Low(n = 185) | 63(34.05) | 100(54.05) | 22(11.89) | CCvs.CG | 0.566 | 1.260(0.572–2.775) |
|  | High(n = 42) | 11(26.19) | 22(52.38) | 9(21.43) | CCvs.GG | 0.092 | 2.343(0.857–6.406) |
| Â | Lymph node metastasis | Â | Â | Â | Â | Â | Â |
|  | Yes(n = 31) | 10(32.26) | 17(54.84) | 4(12.90) | CCvs.CG | 0.934 | 0.965(0.416–2.237) |
|  | No(n = 196) | 64(32.65) | 105(53.57) | 27(13.78) | CCvs.GG | 0.933 | 1.055(0.304–3.658) |
rs10733113 | Â | GG n(%) | GA n(%) | AA n(%) | Â | Â | Â |
| Â | Pathological types | Â | Â | Â | Â | Â | Â |
|  | Squamous carcinoma(n = 171) | 119(69.59) | 43(25.15) | 9(5.26) | GGvs.GA | 0.772 | 0.899(0.439–1.841) |
|  | Adenocarcinoma(n = 56) | 40(71.43) | 13(23.21) | 3(5.36) | GGvs.AA | 0.990 | 0.992(0.256–3.844) |
| Â | TNM stage | Â | Â | Â | Â | Â | Â |
|  | I/II(n = 143) | 98(68.53) | 37(25.87) | 8(5.60) | GGvs.GA | 0.555 | 0.825(0.435–1.563) |
|  | III/IV(n = 84) | 61(72.62) | 19(22.62) | 4(4.76) | GGvs.AA | 0.729 | 0.803(0.232–2.782) |
| Â | Differentiated degree | Â | Â | Â | Â | Â | Â |
|  | Low(n = 185) | 129(69.73) | 47(25.41) | 9(4.86) | GGvs.GA | 0.640 | 0.823(0.364–1.863) |
|  | High(n = 42) | 30(71.43) | 9(21.43) | 3(7.14) | GGvs.AA | 0.604 | 1.433(0.366–5.616) |
| Â | Lymph node metastasis | Â | Â | Â | Â | Â | Â |
|  | Yes(n = 31) | 21(67.74) | 9(29.03) | 1(3.23) | GGvs.GA | 0.595 | 0.795(0.340–1.856) |
|  | No(n = 196) | 138(70.41) | 47(23.98) | 11(5.61) | GGvs.AA | 0.627 | 1.674(0.205–13.642) |