Table 5 NLRP3 polymorphism genotype and allele distribution frequencies in the control, CC, and CIN groups
SNP | Genotype | Controls(n = 419) | CC(n = 227) | P1 | OR (95%CI) | CIN(n = 177) | P2 | OR (95%CI) |
|---|---|---|---|---|---|---|---|---|
rs10754558 | CC | 166(39.62) | 74(32.60) | Â | 1.000 | 56(31.64) | Â | 1.000 |
|  | CG | 215(51.31) | 122(53.74) | 0.180 | 1.273(0.895–1.811) | 98(55.37) | 0.126 | 1.351(0.919–1.987) |
|  | GG | 38(9.07) | 31(13.66) | 0.029 | 1.830(1.058–3.165) | 23(12.99) | 0.054 | 1.794(0.985–3.269) |
|  | CG + GG | 253(60.38) | 153(67.40) | 0.078 | 1.357(0.966–1.905) | 121(68.36) | 0.066 | 1.418(0.977–2.057) |
| Â | GG | 38(9.07) | 31(13.66) | Â | 1.000 | 23(12.99) | Â | 1.000 |
|  | CC + CG | 381(90.93) | 196(86.34) | 0.072 | 0.631(0.381–1.045) | 154(87.00) | 0.149 | 0.668(0.385–1.158) |
| Â | C Allele | 547(65.27) | 270(59.47) | Â | 1.000 | 210(59.32) | Â | 1.000 |
|  | G Allele | 291(34.73) | 184(40.53) | 0.039 | 1.281(1.012–1.621) | 144(40.68) | 0.051 | 1.289(0.999–1.664) |
rs10733113 | GG | 291(69.45) | 159(70.04) | Â | 1.000 | 120(67.80) | Â | 1.000 |
|  | GA | 106(25.30) | 56(24.67) | 0.861 | 0.976(0.663–1.410) | 48(27.12) | 0.648 | 1.098(0.735–1.641) |
|  | AA | 22(5.25) | 12(5.29) | 0.996 | 0.998(0.481–2.070) | 9(5.08) | 0.984 | 0.992(0.444–2.217) |
|  | GA + AA | 128(30.55) | 68((29.96) | 0.876 | 0.972(0.684–1.382) | 57(32.20) | 0.690 | 1.080(0.740–1.575) |
| Â | AA | 22(5.25) | 12(5.29) | Â | 1.000 | 9(5.08) | Â | 1.000 |
|  | GG + GA | 397(94.75) | 215(94.71) | 0.985 | 0.993(0.482–2.045) | 168(94.92) | 0.934 | 1.034(0.467–2.293) |
| Â | G Allele | 688(82.10) | 374(82.38) | Â | 1.000 | 288(81.36) | Â | 1.000 |
|  |  A Allele | 150(17.90) | 80(17.62) | 0.901 | 0.981(0.727–1.323) | 66(18.64) | 0.760 | 1.051(0.763–1.448) |