Table 4 Analyses of NLRP3 polymorphism genotype distributions by age
Age genotype | Cases(n = 404) | Controls(n = 419) | P value | OR(95%CI) |
|---|---|---|---|---|
rs10754558 | Â | Â | Â | Â |
≤ 45 years old | n = 128 | n = 135 |  |  |
CC | 47(36.72) | 57(42.22) | Â | 1.000 |
CG | 62(48.44) | 64(47.41) | 0.544 | 1.175(0.698–1.978) |
GG | 19(14.84) | 14(10.37) | 0.215 | 1.646(0.746–3.630) |
CG + GG | 81(63.28) | 78(57.78) | 0.362 | 1.259(0.767–2.068) |
GG | 19(14.84) | 14(10.37) | Â | 1.000 |
CG + CC | 109(85.16) | 121(89.63) | 0.274 | 0.664(0.318–1.387) |
> 45 years old | n = 276 | n = 284 |  |  |
CC | 86(31.16) | 109(38.38) | Â | 1.000 |
CG | 155(56.16) | 151(53.17) | 0.152 | 1.301(0.907–1.866) |
GG | 35(12.68) | 24(8.45) | 0.040 | 1.848(1.023–3.339) |
CG + GG | 190(68.84) | 175(61.62) | 0.073 | 1.376(0.970–1.952) |
GG | 35(12.68) | 24(8.45) | Â | 1.000 |
CG + CC | 241(87.32) | 260(91.55) | 0.103 | 0.636(0.367-1.100) |
rs10733113 | Â | Â | Â | Â |
≤ 45 years old | n = 128 | n = 135 |  |  |
GG | 85(66.41) | 82(60.74) | Â | 1.000 |
GA | 38(29.69) | 46(34.07) | 0.397 | 0.797(0.471–1.348) |
AA | 5(3.91) | 7(5.19) | 0.537 | 0.689(0.210–2.258) |
GA + AA | 43(33.59) | 53(39.26) | 0.885 | 0.965(0.593–1.570) |
AA | 5((3.91) | 7(5.19) | Â | 1.000 |
GG + GA | 123(96.09) | 128(94.81) | 0.619 | 1.345(0.416–4.352) |
> 45 years old | n = 276 | n = 284 |  |  |
GG | 194(70.29) | 209(73.59) | Â | 1.000 |
GA | 66(23.91) | 60(21.13) | 0.406 | 1.185(0.794–1.769) |
AA | 16(5.80) | 15(5.28) | 0.709 | 1.149(0.553–2.387) |
GA + AA | 82(29.71) | 75(26.41) | 0.384 | 1.178(0.814–1.704) |
AA | 16(5.80) | 15(5.28) | Â | 1.000 |
GG + GA | 260(94.20) | 269(94.72) | 0.790 | 0.906(0.439–1.870) |