Human parvovirus B19 infection in malignant and benign tissue specimens of different head and neck anatomical subsites

Table 3 p16^INK4a and NF-κB immunoreactivity in different anatomical sites of B19V-positive and -negative HNSCCs

		HNSCC anatomic site N (%)
		Tongue N = 38	Oral cavity N = 34	Larynx N = 13	Hypopharynx N = 9	Nasopharynx N = 8	Tonsil N = 6
B19V DNA (+)	p16^INK4a (+)	3 (7.9)	4 (14.8)	2 (18.2)	0	2 (28.6)	2 (40)
B19V DNA (+)	p16^INK4a (-)	9 (23.7)	5 (18.5)	3 (27.3)	3 (33.3)	1 (14.3)	0
B19V DNA (−)	p16^INK4a (+)	6 (15.8)	9 (33.3)	2 (18.2)	1 (11.1)	0	1 (20)
B19V DNA (−)	p16^INK4a (-)	20 (52.6)	9 (33.3)	4 (36.4)	5 (55.6)	4 (57.1)	2 (40)
B19V DNA (+)	High cytoplasmic NF-κB expression	8 (21.6)	10 (31.3)	4 (33.3)	2 (25)	2 (28.6)	1 (20)
B19V DNA (+)	Low cytoplasmic NF-κB expression	4 (10.8)	1 (3.1)	1 (8.3)	1 (12.5)	1 (14.3)	1 (20)
B19V DNA (−)	High cytoplasmic NF-κB expression	18 (48.6)	15 (46.9)	5 (41.7)	4 (50)	2 (28.6)	2 (40)
B19V DNA (−)	Low cytoplasmic NF-κB expression	7 (18.9)	6 (18.8)	2 (16.7)	1 (12.5)	2 (28.6)	1 (20)
B19V DNA (+)	High nuclear NF-κB expression	0	4 (12.5)	3 (25)	2 (25)	0	0
B19V DNA (+)	Low nuclear NF-κB expression	12 (32.4)	7 (21.9)	2 (16.7)	1 (12.5)	3 (42.9)	2 (40)
B19V DNA (−)	High nuclear NF-κB expression	5 (13.5)	4 (12.5)	1 (8.3)	3 (37.5)	1 (14.3)	1 (20)
B19V DNA (−)	Low nuclear NF-κB expression	20 (54.1)	17 (53.1)	6 (50)	2 (25)	3 (42.9)	2 (40)

p16INK4a, cytoplasmic NF-κB, and nuclear NF-κB immunohistochemistry were successfully performed on 97, 101, and 101 of the total 108 HNSCC specimens, respectively

ISSN: 1750-9378