Table 2 Associations between demographic/histopathological features and parvovirus B19 status among patients with head and neck squamous cell carcinoma
Characteristics | All Patients (%) N = 108 | B19V DNA positive (%) N = 39 | B19V DNA negative (%) N = 69 | p-value | B19V IHC positive (%) †N = 24 | B19V IHC negative (%) †N = 79 | p-value | |
|---|---|---|---|---|---|---|---|---|
Age (years) | < 56 | 58 (53.7) | 24 (61.5) | 34 (49.3) | 0.235 | 15 (62.5) | 40 (50.6) | 0.356 |
≥ 56 | 50 (46.3) | 15 (38.5) | 35 (50.7) | 9 (37.5) | 39 (49.4) | |||
Gender | Male | 63 (58.3) | 25 (64.1) | 38 (55.1) | 0.419 | 15 (62.5) | 45 (57) | 0.647 |
Female | 45 (41.7) | 14 (35.9) | 31 (44.9) | 9 (37.5) | 34 (43) | |||
Anatomic site | Tongue | 38 (35.2) | 12 (30.8) | 26 (37.7) | 0.949 | 8 (33.3) | 30 (38) | 0.660 |
Oral Cavity | 34 (31.5) | 13 (33.3) | 21 (30.4) | 7 (29.2) | 25 (31.6) | |||
Larynx | 13 (12.0) | 5 (12.8) | 8 (11.6) | 4 (16.7) | 8 (10.1) | |||
Hypopharynx | 9 (8.3) | 3 (7.7) | 6 (8.7) | 3 (12.5) | 5 (6.3) | |||
Nasopharynx | 8 (7.4) | 4 (10.3) | 4 (5.8) | 2 (8.3) | 6 (7.6) | |||
Tonsil | 6 (5.6) | 2 (5.1) | 4 (5.8) | 0 | 5 (6.3) | |||
Grade (Differentiation) | Well | 61 (56.5) | 26 (66.7) | 35 (50.7) | 0.191 | 13 (54.2) | 44 (55.7) | 0.746 |
Moderately | 33 (30.6) | 8 (20.5) | 25 (36.2) | 6 (25) | 26 (32.9) | |||
Poorly | 10 (9.3) | 3 (7.7) | 7 (10.1) | 3 (12.5) | 7 (8.9) | |||
Not Recorded | 4 (3.7) | 2 (5.1) | 2 (3) | 2 (8.3) | 2 (2.5) | |||
p16INK4a Expression | Positive | 32 (29.6) | 13 (33.3) | 19 (27.5) | 0.498 | 6 (25) | 26 (32.9) | 0.610 |
Negative | 65 (60.2) | 21 (53.8) | 44 (63.8) | 16 (66.7) | 48 (60.8) | |||
ND | 11 (10.2) | 5 (12.8) | 6 (8.7) | 2 (8.3) | 5 (6.3) | |||
Cytoplasmic NF-κB Expression | High | 73 (67.6) | 27 (69.2) | 46 (66.7) | 0.816 | 18 (75) | 55 (69.6) | 0.599 |
Low | 28 (25.9) | 9 (23.1) | 19 (27.5) | 5 (20.8) | 23 (29.1) | |||
ND | 7 (6.5) | 3 (7.7) | 4 (5.8) | 1 (4.2) | 1 (1.3) | |||
Nuclear NF-κB Expression | High | 24 (22.2) | 9 (23.1) | 15 (21.7) | 0.812 | 7 (29.2) | 17 (21.5) | 0.411 |
Low | 77(71.3) | 27 (69.2) | 50 (72.5) | 16 (66.7) | 61 (77.2) | |||
ND | 7 (6.5) | 3 (7.7) | 4 (5.8) | 1 (4.2) | 1 (1.3) | |||