Table 5 List of DEGs directly interacting with risk factors or drug chemicals inferred from the comparative toxicogenomic database
Gene | Evidence type | Inference network | Inference score | Reference count | Population |
|---|---|---|---|---|---|
PTGS2 | Marker/mechanism | 4-Nitroquinoline-1-oxide | Cisplatin | diallyl trisulfide | Docetaxel | Fluorouracil | Mitomycin | nitrosobenzylmethylamine | Tobacco Smoke Pollution | Vinorelbine | Zinc | 9.41 | 14 | African American, Brazilian, European |
SLC39A6 | Therapeutic (LADIRATUZUMAB VEDOTIN-Zinc transporter ZIP6 binding agent) for tripple -ve breast cancer and angiosarcoma | Tobacco Smoke Pollution | Zinc | 4.9 | 7 | African American |
TAGLN | Marker/mechanism | Cisplatin | Fluorouracil | Tobacco Smoke Pollution | 5.5 | 5 | African American |
HMGN5 | Marker/mechanism | Cisplatin | Fluorouracil | Tobacco Smoke Pollution | 8.74 | 5 | African American, European |
KRT17 | Marker/mechanism | Cisplatin | Fluorouracil | nitrosobenzylmethylamine | Tobacco Smoke Pollution | 10.22 | 6 | African American, Brazilian, European, Chinese |
FAT1 | Marker/mechanism | Mitomycin | nitrosobenzylmethylamine | Tobacco Smoke Pollution | 10.22 | 6 | Brazilian, European |
SERPINB3 | Marker/mechanism | nitrosobenzylmethylamine | Tobacco Smoke Pollution | Zinc | 9.69 | 8 | Chinese, European, Taiwanese |
ALDH2 | Marker/mechanism | Cisplatin | nitrosobenzylmethylamine | Tobacco Smoke Pollution | Zinc | 7.51 | 11 | European |
ANXA1 | Marker/mechanism | Cisplatin | diallyl trisulfide | Fluorouracil | nitrosobenzylmethylamine | Tobacco Smoke Pollution | Zinc | 13.15 | 11 | European |
SALL4 | Marker/mechanism | Cisplatin | Tobacco Smoke Pollution | 4.95 | 5 | European |
TPM1 | Marker/mechanism | Cisplatin | Fluorouracil | Tobacco Smoke Pollution | Zinc | 8.18 | 9 | European |