Fig. 1

Volcano plots and Venn diagrams of DEGs selected from three datasets. A. Volcano plots of DEGs from GSE47197, GSE84402 and GSE14520 datasets. The red dots and green dots were up-regulated and down-regulated DEGs. B. Venn diagram of upregulated (left) and downregulated (right) DEGs based on the three datasets, including 53 upregulated genes and 219 downregulated genes. C. The PPI network was constructed using STRING and visualized by Cytoscape. The red and green circulars represented up and down, respectively. D. The key modules were identified using the MCODE plugin of Cytoscape. E. The 6 key genes were screened in the PPI network by Cytohubba plugin of Cytoscape based on degree. These key genes were displayed from red (high degree value) to yellow (low degree value)