p16INK4a and pRb expression in laryngeal squamous cell carcinoma with and without infection by EBV or different genotypes of HPV: a retrospective study

Vazquez-Guillen, Jose Manuel; Palacios-Saucedo, Gerardo C.; Alanis-Valdez, Alondra Yamileth; Huerta-Escobedo, Andrea; Zavala-Pompa, Angel; Rivera-Morales, Lydia Guadalupe; Martinez-Torres, Ana Carolina; Gonzalez-Villasana, Vianey; Serna-Hernandez, Julio Cesar; Hernandez-Martinez, Silvia Judith; Castelan-Maldonado, Edmundo Erbey; Montalvo-Bañuelos, Martha Socorro; Alonso-Tellez, Cesar Alejandro; Sanchez-Fresno, Ethel Corinthia; Tamez-Guerra, Reyes S.; Rodriguez-Padilla, Cristina

doi:10.1186/s13027-023-00514-x

Table 2 Clinical data and status of p16^INK4a and pRb expression in 42 laryngeal squamous cell carcinoma patients positive for at least one high-risk human papillomavirus

From: p16^INK4a and pRb expression in laryngeal squamous cell carcinoma with and without infection by EBV or different genotypes of HPV: a retrospective study

Patient no.	Sex	Age	Anatomical location	Grade	Smoking	Alcoholism	HPV genotype	EBV	p16^INK4a	pRb
007	M	≥ 60	Subglottic	II	Yes	Yes	11, 52	−	Negative	Positive
009	M	< 60	Transglottic	I	Yes	No	16	−	Negative	Negative
010	M	≥ 60	Glottic	I	Yes	No	52	−	Negative	Positive
013	M	≥ 60	Supraglottic	II	Yes	No	52	−	Positive	Positive
015	M	≥ 60	Glottic	III	Yes	No	16	−	Negative	Positive
029	M	≥ 60	Supraglottic	II	Yes	No	11, 16	−	Positive	Positive
045	M	≥ 60	Glottic	III	Yes	No	11, 52	−	Positive	Negative
046	M	≥ 60	Glottic	II	Yes	No	11, 16	−	Positive	Negative
047	M	≥ 60	Transglottic	III	Yes	No	6, 11, 52	−	Negative	Negative
049	M	≥ 60	Transglottic	II	Yes	No	11, 52	−	Negative	Negative
051	M	≥ 60	Supraglottic	I	Yes	No	6, 11, 52	−	Positive	Positive
052	M	≥ 60	Glottic	I	Yes	No	16, 52	−	Positive	Positive
053	M	≥ 60	Transglottic	I	Yes	No	11, 52	−	Negative	Negative
056	M	≥ 60	Glottic	II	Yes	No	11, 45	−	Negative	Negative
059	M	< 60	Transglottic	II	Yes	No	52	+	Positive	Negative
060	M	≥ 60	Glottic	II	Yes	No	11, 52	−	Positive	Positive
061	M	≥ 60	Glottic	I	Yes	Yes	11, 16	−	Negative	Positive
062	M	≥ 60	Transglottic	II	Yes	No	6, 11, 52	−	Negative	Positive
063	M	< 60	Subglottic	I	Yes	No	11, 31, 52, 54	+	Positive	Negative
067	M	< 60	Glottic	I	Yes	No	6, 11, 52	+	Positive	Positive
068	M	≥ 60	Transglottic	II	Yes	Yes	11, 16, 52	+	Negative	Positive
069	M	< 60	Transglottic	I	Yes	No	11, 52	−	Positive	Positive
070	M	≥ 60	Transglottic	II	No	No	11, 52	+	Positive	Positive
071	M	≥ 60	Transglottic	I	Yes	No	11, 31, 52, 54	−	Positive	Positive
072	M	≥ 60	Transglottic	I	Yes	No	11, 52	−	Negative	Negative
074	M	≥ 60	Supraglottic	II	Yes	No	11, 31, 52, 54	+	Negative	Negative
075	M	≥ 60	Glottic	III	Yes	No	11, 26, 31, 52, 54	+	Positive	Positive
079	M	≥ 60	Glottic	II	Yes	No	11, 31, 52, 54	−	Positive	Positive
080	M	< 60	Glottic	I	Yes	No	11, 52	−	Negative	Negative
084	M	< 60	Glottic	II	Yes	No	6, 11, 16, 52	−	Positive	Negative
085	M	≥ 60	Supraglottic	II	Yes	No	11, 52	−	Positive	Negative
088	M	≥ 60	Transglottic	II	Yes	No	6, 11, 52	+	Negative	Negative
089	M	≥ 60	Glottic	I	Yes	No	11, 52	−	Positive	Negative
090	M	≥ 60	Transglottic	I	Yes	No	11, 31, 52	+	Positive	Positive
091	M	≥ 60	Glottic	II	Yes	No	11, 52	−	Positive	Positive
092	M	≥ 60	Transglottic	I	Yes	No	11, 31, 52	−	Negative	Positive
097	M	< 60	Glottic	I	Yes	No	52	−	Negative	Positive
099	M	≥ 60	Supraglottic	III	Yes	No	52	−	Positive	Positive
124	F	≥ 60	Glottic	I	Yes	No	45	−	Positive	Positive
141	M	< 60	Glottic	II	Yes	No	52	−	Negative	Positive
148	M	≥ 60	Glottic	II	Yes	No	52	+	Negative	Positive
149	M	≥ 60	Glottic	II	No	No	45	+	Negative	Positive

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ISSN: 1750-9378

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