Skip to main content

Table 1 Correlation of p16INK4a and pRb expression with clinicopathological characteristics of 103 patients with laryngeal squamous cell carcinoma

From: p16INK4a and pRb expression in laryngeal squamous cell carcinoma with and without infection by EBV or different genotypes of HPV: a retrospective study

 

Total (n = 103)

p16INK4a positivea (n = 55)

p16INK4a negativeb (n = 48)

p

pRb positivec (n = 78)

pRb negatived (n = 25)

p

Age (years)

64 (40–89)

64 (43–87)

63.5 (40–89)

0.086

64 (40–89)

64.5 (46–81)

0.216

Age ≥ 60 years

76 (73.8%)

40 (52.6%)

36 (47.4%)

0.793

59 (77.6%)

17 (22.4%)

0.456

Sex

   

1.000

  

0.570

 Male

99 (96.1%)

53 (53.5%)

46 (46.5%)

 

74 (74.7%)

25 (25.3%)

 

 Female

4 (3.9%)

2 (50.0%)

2 (50.0%)

 

4 (100%)

0 (0.0%)

 

Surgical sample

   

0.009

  

0.025

 Biopsy

57 (55.3%)

37 (64.9%)

20 (35.1%)

 

48 (84.2%)

9 (15.8%)

 

 Laryngectormy

46 (44.7%)

18 (39.1%)

28 (60.9%)

 

30 (65.2%)

16 (34.8%)

 

Anatomic location

   

0.575

  

0.436

 Glottic

51 (49.5%)

28 (54.9%)

23 (45.1%)

 

42 (81.4%)

9 (17.6%)

 

 Subglottic

4 (3.9%)

2 (50.0%)

2 (50.0%)

 

3 (75.0%)

1 (25.0%)

 

 Supraglottic

15 (14.6%)

10 (66.7%)

5 (33.3%)

 

11 (73.3%)

4 (26.7%)

 

 Transglottic

33 (32.0%)

15 (45.4%)

18 (54.6%)

 

22 (66.7%)

11 (33.3%)

 

Hitopathological grade

   

0.010

  

0.421

 Grade I

44 (42.7%)

22 (50.0%)

22 (50.0%)

 

35 (79.5%)

9 (20.5%)

 

 Grade II

38 (36.9%)

16 (42.1%)

22 (57.9%)

 

26 (68.4%)

12 (31.6%)

 

 Grade III

21 (20.4%)

17 (80.9%)

4 (19.1%)

 

17 (81.0%)

4 (19.0%)

 

Smoking

101 (98.0%)

54 (53.5%)

47 (46.5%)

1.000

76 (75.2%)

25 (24.8%)

1.000

Alcoholism

7 (6.8%)

1 (14.3%)

6 (85.7%)

0.048

6 (85.7%)

1 (14.3%)

1.000

HPV infection

   

0.557

  

0.021

 Postitive

57 (55.3%)

32 (56.1%)

25 (43.9%)

 

38 (66.7%)

19 (33.3%)

 

 Negative

46 (44.7%)

23 (50.0%)

23 (50.0%)

 

40 (87.0%)

6 (13.0%)

 

HR-HPV infection

   

1.000

  

0.010

 Positive

42 (40.8%)

22 (52.4%)

20 (47.6%)

 

26 (61.9%)

16 (38.1%)

 

 Negative

61 (59.2%)

33 (54.1%)

28 (45.9%)

 

52 (85.2%)

9 (14.8%)

 

EBV infection

   

0.119

  

1.000

 Positive

28 (27.2%)

11 (39.3%)

17 (60.7%)

 

21 (75.0%)

7 (25.0%)

 

 Negative

75 (72.8%)

44 (58.7%)

31 (41.3%)

 

57 (76.0%)

18 (24.0%)

 

Coinfections

       

 HPV + EBV

16 (15.5%)

11 (68.8%)

5 (31.2%)

0.529

9 (56.3%)

7 (43.7%)

1.000

 HR-HPV + EBV

11 (10.7%)

7 (63.6%)

4 (36.4%)

0.455

6 (54.5%)

5 (45.5%)

1.000

  1. Values are shown in absolute frequencies (percent)
  2. a≥ of 25% of staining cells
  3. b< of 25% of staining cells
  4. c≥ of 75% of staining cells
  5. d< of 75% of staining cells
Back to article page

Infectious Agents and Cancer

ISSN: 1750-9378

Contact us