Conventional therapy for genital herpesvirus and remission of HPV-related lesions: a case series

Table 1 Clinical data of patients

ID	Age	Genital HHV-2	PAP TEST HPV-DNA	Condylomatosis	Other STI	Oral antiviral dosage	ACV/VCV topical dosage	Times of remission (d, m, y)
A	B	C	D	E	F	G	H	I
6	27	Cervical lesions	ASCUS HPV16-HPV66	Vulvar micro-condylomatosis	Severe candidiasis	VCV 3000 mg/d/90d	No	2 m
12	39	Vulvar lesions	NILM	Vulvar micro-condylomatosis	(Past laser treatment of CIN2)	ACV 1600 mg/d/15d	No, due to vulvodynia	20d
17	27	Vulvar lesions	L-SIL HPV16-HPV42	Vulvar condylomatosis	Candidiasis	VCV 2000 mg/d/30d	5% (2x/d/20d)	2 m
25	40	Vulvar and cervical lesions	NILM	Vulvar micro-condylomatosis	Vulvo-perineal candidiasis	ACV 1600 mg/d/15d	5% (3x/d/10d) 2 times with 7d interval	15d
29	42	Cervical lesions	L-SIL HPV negative	Vulvar micro-condylomatosis	Candidiasis	VCV 1000 mg/d/42d	No	5 m
32	40	Vulvar HHV-2 recurrent	H-SIL CIN2 HPV16	Perineal and anal condylomatosis	Candidiasis	VCV 2000 mg/d/90d	5% (1x/d/45d)	6 m
37	48	Vulvar lesions	LSIL HPV16	nd	nd		5% ACV (intravaginal appl 4x/d/15d) 4 times with 7d interval	7 m

The columns report from left to right in order: A) ID patient identification number, B) age, C) presence of clinical herpesvirus (HHV) lesions, D) PAP and HPV-DNA test results, E) presence of condylomatosis, F) Candida co-infections, G) ACV or VCV oral antiviral dosage, H) topical dosage administered and I) time of remission, indicating the time elapsed from the first visit to the visit in which the restitutio ad integrum of the tissue was ascertained. HPV DNA test was not performed in ID12 and ID25 patients, because their Pap-test result did not show cytology abnormalities
HPV Human Papillomavirus; ASC-US atypical squamous cells of undetermined significance; NILM Negative for intra-epithelial lesions and malignancy; LSIL Low-grade Squamous intraepithelial lesion; HSIL high-grade Squamous intraepithelial lesion; HHV Human Herpesvirus; ACV Acyclovir; VCV Valacyclovir; d day/s; m: month/s; y year/s. 1x; 2x; 3x:1, 2, 3 times repeated; Nd not detected; Appl application

ISSN: 1750-9378