Table 1 Baseline characteristics of the included cancer patients who died due to infectious disease
| Â | Overall | Other infectious and parasitic diseases, including HIV | Pneumonia and influenza | Septicemia | Syphilis | Tuberculosis | P value | |
|---|---|---|---|---|---|---|---|---|
n | 151,440 | 47,310 | 72,133 | 31,119 | 35 | 843 | Â | |
Age, mean (SD) in years | 66.33 (17.18) | 51.51 (17.11) | 74.43 (11.82) | 70.00 (12.77) | 67.77 (17.33) | 69.17 (12.92) |  < 0.001 | |
Sex (%) | ||||||||
Female | 57,511 (38.0) | 10,912 (23.1) | 31,595 (43.8) | 14,689 (47.2) | 15 (42.9) | 300 (35.6) |  < 0.001 | |
Male | 93,929 (62.0) | 36,398 (76.9) | 40,538 (56.2) | 16,430 (52.8) | 20 (57.1) | 543 (64.4) | Â | |
Survival, mean (SD) in months | 65.31 (78.17) | 38.12 (61.18) | 81.09 (81.72) | 70.14 (81.85) | 74.10 (87.83) | 57.43 (69.14) |  < 0.001 | |
Grade (%) | ||||||||
B-cell; pre-B; B-precursor | 7818 (5.2) | 4899 (10.4) | 1898 (2.6) | 1001 (3.2) | 1 (2.9) | 19 (2.3) |  < 0.001 | |
Moderately differentiated; Grade II | 33,347 (22.0) | 5243 (11.1) | 19,510 (27.0) | 8384 (26.9) | 11 (31.4) | 199 (23.6) | Â | |
NK cell; natural killer cell (1995+) | 20 (0.0) | 11 (0.0) | 4 (0.0) | 4 (0.0) | 0 (0.0) | 1 (0.1) | Â | |
Null cell; non-T-non-B | 36 (0.0) | 22 (0.0) | 10 (0.0) | 4 (0.0) | 0 (0.0) | 0 (0.0) | Â | |
Poorly differentiated; Grade III | 20,022 (13.2) | 3458 (7.3) | 11,114 (15.4) | 5330 (17.1) | 3 (8.6) | 117 (13.9) | Â | |
T-cell | 709 (0.5) | 428 (0.9) | 182 (0.3) | 96 (0.3) | 0 (0.0) | 3 (0.4) | Â | |
Undifferentiated; anaplastic; Grade IV | 4096 (2.7) | 1135 (2.4) | 2002 (2.8) | 933 (3.0) | 2 (5.7) | 24 (2.8) | Â | |
Unknown | 72,008 (47.5) | 30,021 (63.5) | 29,289 (40.6) | 12,279 (39.5) | 15 (42.9) | 404 (47.9) | Â | |
Well differentiated; Grade I | 13,384 (8.8) | 2093 (4.4) | 8124 (11.3) | 3088 (9.9) | 3 (8.6) | 76 (9.0) | Â | |
Laterality (%) | ||||||||
Bilateral, single primary | 1198 (0.8) | 739 (1.6) | 290 (0.4) | 160 (0.5) | 2 (5.7) | 7 (0.8) |  < 0.001 | |
Left—origin of primary | 20,467 (13.5) | 5006 (10.6) | 10,792 (15.0) | 4542 (14.6) | 4 (11.4) | 123 (14.6) |  | |
Not a paired site | 104,929 (69.3) | 35,125 (74.2) | 48,181 (66.8) | 21,046 (67.6) | 23 (65.7) | 554 (65.7) | Â | |
Only one side—side unspecified | 331 (0.2) | 114 (0.2) | 139 (0.2) | 74 (0.2) | 0 (0.0) | 4 (0.5) |  | |
Paired site, but no information concerning laterality | 2177 (1.4) | 949 (2.0) | 879 (1.2) | 326 (1.0) | 0 (0.0) | 23 (2.7) | Â | |
Paired site: midline tumour | 31 (0.0) | 8 (0.0) | 15 (0.0) | 8 (0.0) | 0 (0.0) | 0 (0.0) | Â | |
Right—origin of primary | 22,307 (14.7) | 5369 (11.3) | 11,837 (16.4) | 4963 (15.9) | 6 (17.1) | 132 (15.7) |  | |
Race (%) | ||||||||
American Indian/Alaska Native | 738 (0.5) | 292 (0.6) | 285 (0.4) | 148 (0.5) | 1 (2.9) | 12 (1.4) |  < 0.001 | |
Asian or Pacific Islander | 7494 (4.9) | 2074 (4.4) | 3948 (5.5) | 1313 (4.2) | 0 (0.0) | 159 (18.9) | Â | |
Black | 19,020 (12.6) | 8249 (17.4) | 5647 (7.8) | 4951 (15.9) | 10 (28.6) | 163 (19.3) | Â | |
Unknown | 711 (0.5) | 213 (0.5) | 423 (0.6) | 68 (0.2) | 0 (0.0) | 7 (0.8) | Â | |
White | 123,477 (81.5) | 36,482 (77.1) | 61,830 (85.7) | 24,639 (79.2) | 24 (68.6) | 502 (59.5) | Â | |
Behavior (%) | ||||||||
Benign | 1067 (0.7) | 234 (0.5) | 497 (0.7) | 331 (1.1) | 2 (5.7) | 3 (0.4) |  < 0.001 | |
Borderline malignancy | 2182 (1.4) | 525 (1.1) | 890 (1.2) | 745 (2.4) | 0 (0.0) | 22 (2.6) | Â | |
In situ | 8110 (5.4) | 2188 (4.6) | 4082 (5.7) | 1796 (5.8) | 4 (11.4) | 40 (4.7) | Â | |
Malignant | 140,081 (92.5) | 44,363 (93.8) | 66,664 (92.4) | 28,247 (90.8) | 29 (82.9) | 778 (92.3) | Â | |
Marital status (%) | ||||||||
Divorced | 10,617 (7.0) | 3768 (8.0) | 4358 (6.0) | 2424 (7.8) | 2 (5.7) | 65 (7.7) |  < 0.001 | |
Married | 64,925 (42.9) | 12,993 (27.5) | 35,789 (49.6) | 15,691 (50.4) | 17 (48.6) | 435 (51.6) | Â | |
Separated | 2043 (1.3) | 566 (1.2) | 1036 (1.4) | 413 (1.3) | 1 (2.9) | 27 (3.2) | Â | |
Single | 34,464 (22.8) | 23,609 (49.9) | 7133 (9.9) | 3607 (11.6) | 8 (22.9) | 107 (12.7) | Â | |
Unknown | 9519 (6.3) | 2709 (5.7) | 4562 (6.3) | 2185 (7.0) | 0 (0.0) | 63 (7.5) | Â | |
Unmarried or domestic Partner | 39 (0.0) | 31 (0.1) | 4 (0.0) | 4 (0.0) | 0 (0.0) | 0 (0.0) | Â | |
Widowed | 29,833 (19.7) | 3634 (7.7) | 19,251 (26.7) | 6795 (21.8) | 7 (20.0) | 146 (17.3) | Â | |