From: Identification of key genes in hepatitis B associated hepatocellular carcinoma based on WGCNA
Gene | Ensembl ID | Description | Alias | Summary |
---|---|---|---|---|
CCNB1 | ENSG00000134057.14 | cyclin B1 | CCNB | The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. |
GINS1 | ENSG00000101003.9 | GINS complex subunit 1 | PSF1 | The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts. |
PRC1 | ENSG00000198901.13 | protein regulator of cytokinesis 1 | ASE1 | This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters mitosis G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. |
KIF20A | ENSG00000112984.11 | kinesin family member 20A | MKLP2, RAB6KIFL | – |
NUSAP1 | ENSG00000137804.12 | nucleolar and spindle associated protein 1 | ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL | NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization. |
NEK2 | ENSG00000117650.12 | – | – | – |
BUB1B | ENSG00000156970.12 | BUB1 mitotic checkpoint serine/threonine kinase B | BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 | This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. |