From: Prognostic factors in patients with HBV-related hepatocellular carcinoma following hepatic resection
 | Univariate | Multivariate | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Gender (male) | ||||
 female | 0.894 (0.60–1.32) | 0.574 |  |  |
Age (years) | 0.996 (0.97–1.02) | 0.719 |  |  |
HCV (no) | ||||
 yes | 1.473 (0.59–3.62) | 0.399 |  |  |
Platelets × 103 (mm3) | 0.987 (0.96–1.01) | 0.367 |  |  |
AFP-pre (ng/mL) | 0.996 (0.97–1.01) | 0.665 |  |  |
AFP-post (ng/mL) | 1.112 (1.02–1.21) | 0.012 | 1.129 (1.04–1.23) | 0.005 |
Tumor size (< 5 cm) | 1.061 (1.01–1.11) | 0.013 |  |  |
  ≥ 5 cm | 1.345 (0.90–1.99) | 0.139 |  |  |
Number of tumors (solitary) | ||||
 multiple | 1.881 (1.23–2.86) | 0.003 | 1.973 (1.15–3.38) | 0.013 |
Microvascular invasion (no) | ||||
 yes | 1.645 (1.02–2.63) | 0.037 |  |  |
Stage (I) | ||||
 II or higher | 1.553 (1.04–2.31) | 0.031 |  |  |
Resection margin (free margin) | ||||
 positive margin | 0.977 (0.35–2.66) | 0.964 |  |  |
Operation type (anatomical) | ||||
 non-anatomical | 0.708 (0.47–1.05) | 0.085 |  |  |
Preoperative neoadjuvant (no) | ||||
 yes | 0.828 (0.51–1.34) | 0.450 |  |  |
Platelet-to-lymphocyte ratio | 0.913 (0.61–1.34) | 0.648 |  |  |
Prognostic nutritional index | 0.959 (0.56–1.61) | 0.875 |  |  |
Neutrophil-to-lymphocyte ratio | 1.052 (0.89–1.23) | 0.535 |  |  |
Antiviral treatment | ||||
 no | 1.519 (1.01–2.28) | 0.045 | 1.823 (1.07–3.09) | 0.026 |
Antiplatelet treatment (ASA + Clopidogrel) | ||||
 no | 1.018 (0.49–2.09) | 0.961 |  |  |