Cell lines | Drug and dosage | Results | References |
---|---|---|---|
MC65 | EGCG 20 μM | EGCG reduced the Aβ levels by enhancing endogenous APP proteolysis and decreased nuclear translocation of c-Abl. | [20] |
EOC 13.31 | EGCG 5 to 20 μM | EGCG suppressed the expression of Aβ-induced TNFα, IL-1β, IL-6, and iNOS, and restored the levels of intracellular antioxidants Nrf2 and HO-1. | [23] |
SweAPP N2a | GTE | EGCG reduced the Aβ generation and activated nonamyloidogenic processing of APP by promoting its α-secretase cleavage. | [24] |
Div8 | EGCG 12.5–50 μM | EGCG induced an increase in the key autophagy adaptor proteins NDP52 and p62. | [27] |
M146 L, CHO | EGCG 16–32 μmol/L | EGCG reduced the accumulation of β-amyloid (Aβ). | [28] |
N2a/APP695 | EGCG (5–100 μM) | EGCG suppressed the production of Aβ and reduced inflammation, oxidative stress and cell apoptosis. | [29] |