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Table 3 Genotypes’ association with HPV status and test for deviation from Hardy-Weinberg Equilibrium

From: HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia

Gene, genotype and allele

HPV+/− n( %)

Odds ratio

P-Value

Deviation from HWE

Cases

Controls

(95% CI)

 

Expected

(HPV+) (n= 82)

(HPV-) (n= 18)

Cases

Controls

XRCC1 codon 399 G>A Arg/Gln (rs25487)

Genotype

      

G/G

42 (51)

11 (61)

  

37.56

10.89

G/A

27 (33)

6 (33)

1.18 (0.39-3.56)

0.77

35.87

6.22

A/A

13 (16)

1 (6)

3.41 (0.40-28.93)

0.24

8.56

0.89

G/A+A/A

40 (49)

7 (39)

1.49 (0.53-4.24)

0.45

  

Allele

      

G

111 (68)

28 (78)

    

A

53 (32)

8 (22)

1.67 (0.71-3.91)

0.23

  

Armitages’ trend test

Common OR= 1.67

0.28

  

Significance level (P-value) for deviation from HWE

0.03

0.88

TP53 (p53) codon 72 G>C Arg/Pro (rs1042522)

Genotype

      

G/G

18 (22)

2 (11)

  

22.03

2.35

G/C

49 (60)

9 (50)

0.61 (0.12-3.07)

0.54

40.95

8.31

C/C

15 (18)

7 (39)

0.24 (0.04-1.32)

0.08

19.03

7.35

G/C+C/C

64 (78)

9 (89)

0.44 (0.09-2.12)

0.29

  

Allele

      

G

85 (52)

13 (36)

    

C

79 (48)

23 (64)

0.53 (0.25-1.11)

0.09

  

Armitages’ trend test:

Common OR= 0.48

0.06

  

Significance level (P-value) for deviation from HWE

0.07

0.72

  1. HWE: Hardy-Weinberg Equilibrium. OR: Odds Ratio.
  2. Computed online at: http://ihg.gsf.de/cgi-bin/hw/hwa1.pl.