Volume 7 Supplement 1

Proceedings of the 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)

Open Access

Evaluation of the AIDS clinical trials group staging criteria for Kaposi Sarcoma in a resource limited setting

  • Fred Okuku1, 2Email author,
  • Jackson Orem1, 2,
  • James Kafeero1,
  • Warren Phipps3, 7,
  • Moses R Kamya2 and
  • Corey Casper3, 4, 5, 6, 7
Infectious Agents and Cancer20127(Suppl 1):P8

DOI: 10.1186/1750-9378-7-S1-P8

Published: 19 April 2012

Background

Kaposi sarcoma (KS) is commonly staged using by the AIDS Clinical Trials Group (ACTG) criteria. The three variables of the ACTG are dichotomized as good risk (0) and poor risk (1). Good risk immune status (I0) is defined as CD4 T-cell count ≥200cells/µl, and poor risk (I1) as CD4 < 200cells/µl. Although validated in the US and Europe, no evaluation has been done in resource-limited settings during the HAART era. We sought to determine whether the ACTG staging criteria is predictive of overall survival among Ugandan patients with HIV-associated KS.

Methods

Data were abstracted from medical records of adult patients with HIV-associated KS seen at the Uganda Cancer Institute (UCI) from 2000-2006. The primary outcome was 2-year overall survival. Vital status at 2 years was determined from the medical chart, or by contacting the patient or next of kin using the phone contact provided in the chart or ART clinic. Survival was modeled using Kaplan-Meier methods. Factors associated with survival were evaluated using Cox proportional hazards.

Results

The median survival time was 468 days (range 0, 5411). At 2 years following KS diagnosis, 165 (40.8%) of participants were alive and 166 (41.1%) had died, while 73(18.1%) were lost to follow-up. Factors associated with death before 2 years from KS diagnosis included T1 tumor stage, S1 stage, nodular lesion morphotype, and trunk edema (Table 1). Baseline CD4 count under 100 cells/µl was associated with decreased survival (HR 1.7, 95%CI 1.26-2.39 and p= 0.001), but ACTG immune status criteria (CD4 under 200 cells/µl) was not.
Table 1

Factors associated with death before 2 years from KS diagnosis

 

Univariate

Multivariate

FACTOR

HR

95%

CI P-value

HR

95%

CI P-value

T1 VS T0

4.13

2.18-7.81

<0.001

4.33

2.36-8.77

<0.001

I1 VS I0

1.25

0.64-2.44

0.52

……..

…………

………..

S1 VS S0

1.71

1.13-2.57

0.01

1.69

1.12-2.53

<0.01

Age (yrs)

0.98

0.96-1.00

0.05

0.98

0.96-1.00

0.01

Nodular KS morphotype

1.50

0.97-2.32

0.07

1.34

0.84-2.15

0.22

Trunk edema

2.91

1.53-5.53

<0.001

2.45

1.27-4.75

0.01

On HAART at diagnosis

0.75

0.54-1.02

0.07

0.62

0.45-0.87

0.01

Receipt of chemotherapy

0.46

0.33-0.65

<0.001

0.29

0.20-0.42

<0.001

* Multivariate analysis adjusted for T, S, age, nodular morphotype, trunk edema, HAART, and chemotherapy.

Conclusions

ACTG criteria Tumor extent (T) and Systemic symptoms (S) were associated with survival; Immune status (I) was not. Factors associated with decreased survival included: baseline CD4 counts <100, age, trunk edema, while receipt of HAART and chemotherapy were associated with increased survival. Studies are needed to validate ACTG staging criteria in sub-Saharan Africa and to identify additional prognostic factors.

Authors’ Affiliations

(1)
Uganda Cancer Institute
(2)
Department of Medicine, Makerere University, College of Health Sciences
(3)
Department of Medicine, University of Washington
(4)
Laboratory Medicine, University of Washington
(5)
Epidemiology, University of Washington
(6)
Global Health, University of Washington
(7)
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center

Copyright

© Okuku et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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