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Figure 5 | Infectious Agents and Cancer

Figure 5

From: Peripheral blood lymphocytes from low-grade squamous intraepithelial lesions patients recognize vaccine antigens in the presence of activated dendritic cells, and produced high levels of CD8 + IFNγ + T cells and low levels of IL-2 when induced to proliferate

Figure 5

Proliferation of PBL from LSIL patients in response to HPV antigens presented by monocytic (a,b) and by dendritic cells (c,d). PBL from two LSIL patients, infected by HPV-16 (P1), and HPV-18 (P2) were incubated with Cervarix®, that contains capsid antigens of HPV-16, and HPV-18, to evaluate the induced proliferation. Carboxifluorescein (CFSE) labeled PBL from patients P1 and P2 were incubated in the presence of soluble Cervarix® (PBL + Cervarix) (b), and PBL alone were used as a control (PBL) (a). CFSE labeled PBL from patients P1 and P2 were cultured with autologous dendritic cells (PBL + DCs), previously “loaded” with Cervarix® (d), or with autologous unloaded dendritic cells as a control (PBL + DCs/Cvx) (c). The percentage of decrease in carboxiflourescein label, as an indicator of cell proliferation is shown under the bar (M1) of each histogram.

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Infectious Agents and Cancer

ISSN: 1750-9378

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