A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in Tobago

McDonald, Alicia C; Jenkins, Frank J; Bunker, Clareann H; Wilson, John W; Patrick, Alan L; Weissfeld, Joel L

doi:10.1186/1750-9378-6-25

Infectious Agents and Cancer

Table 1 Characteristics of all men enrolled at Wave 1, men not at risk and at risk for prostate cancer at Wave 2 or Wave 3 based on Wave 1 screen results, and at-risk men with incomplete and complete follow-up.

From: A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in Tobago

			Risk status after Wave 1				Follow-up
	All		Not at risk		At risk		Incomplete		Complete
	n = 3264		n = 717		n = 2547		n = 756		n = 1791
Characteristic	n¹	%	n¹	%	n¹	%	n¹	%	n¹	%	p-value²
Demographic
Age (years)											<.0001
40-44	624	19.1	59	8.2	565	22.2	151	20.0	414	23.1
45-49	571	17.5	71	9.9	500	19.6	115	15.2	385	21.5
50-59	914	28.0	166	23.2	748	29.4	221	29.2	527	29.4
60-81	1155	35.4	421	58.7	734	28.8	269	35.6	465	26.0
Education	(23)		(7)		(16)		(7)		(9)		0.76
≤11 years	2411	74.4	553	77.9	1858	73.4	553	73.8	1305	73.2
12+ years	830	25.6	157	22.1	673	26.6	196	26.2	477	26.8
Marital status	(26)		(10)		(16)		(7)		(9)		0.13
ever married	2669	82.4	590	83.5	2079	82.1	602	80.4	1477	82.9
never married	569	17.6	117	16.5	452	17.9	147	19.6	305	17.1
Family history of ...
Prostate cancer											0.02
missing	323	9.9	77	10.7	246	9.7	86	11.4	160	8.9
yes	218	6.7	40	5.6	178	7.0	64	8.5	114	6.4
no	2723	83.4	600	83.7	2123	83.4	606	80.2	1517	84.7
History of ...
Smoking	(21)		(7)		(14)		(3)		(11)		<.0001
yes	1410	43.5	341	48.0	1069	42.2	365	48.5	704	39.6
no	1833	56.5	369	52.0	1464	57.8	388	51.5	1076	60.4
Cancer	(43)		(13)		(30)		(9)		(21)		0.002
yes	26	0.8	11	1.6	15	0.6	10	1.3	5	0.3
no	3195	99.2	693	98.4	2502	99.4	737	98.7	1765	99.7
Benign prostatic hypertrophy	(84)		(24)		(60)		(17)		(43)		0.67
yes	248	7.8	78	11.3	170	6.8	53	7.2	117	6.7
no	2932	92.2	615	88.7	2317	93.2	686	92.8	1631	93.3
Entry prostate cancer screen
PSA (ng/mL)	(190)		(190)								<.0001
0.0-0.9	1213	39.5	43	8.2	1170	45.9	306	40.5	864	48.2
1.0-1.9	850	27.7	45	8.5	805	31.6	206	27.2	599	33.4
2.0-2.9	268	8.7	21	4.0	247	9.7	84	11.1	163	9.1
3.0-3.9	150	4.9	26	4.9	124	4.9	58	7.7	66	3.7
4.0-9.9	354	11.5	199	37.8	155	6.1	73	9.7	82	4.6
10+	239	7.8	193	36.6	46	1.8	29	3.8	17	0.9
DRE											<.0001
missing	555	17.0	220	30.7	335	13.2	151	20.0	184	10.3
positive	636	19.5	279	38.9	357	14.0	116	15.3	241	13.5
negative	2073	63.5	218	30.4	1855	72.8	489	64.7	1366	76.3

PSA - prostate-specific antigen, DRE - digital rectal examination
1. Numbers in parentheses indicate missing data
2. Statistical significance (chi-square) of differences between at-risk men with incomplete and complete follow-up

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ISSN: 1750-9378

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