Volume 5 Supplement 1
Upregulation of angiopoietin-like 4 by viral G protein-coupled receptor promotes angiogenesis and vascular permeability in Kaposi’s sarcoma
© Montaner et al; licensee BioMed Central Ltd. 2010
Published: 11 October 2010
These observations suggest that ANGPTL4 is a previously unrecognized target for the treatment of patients with KS. As angiogenesis and increased vessel permeability are common themes in all solid tumors, these results may have a broad impact on our understanding and treatment of cancer.
This work was supported by grant R01CA119911 (National Cancer Institute, NIH). We thank Histoserv, Inc., for its assistance in the processing of the murine tissues. BCJ is a recipient of a predoctoral fellowship from the CNPq-Brazil.
This article has been published as part of Infectious Agents and Cancer Volume 5 Supplement 1, 2010: Proceedings of the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI).The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1.
- Moore PS, Chang Y: Kaposi's sarcoma-associated herpesvirus-encoded oncogenes and oncogenesis. J Natl Cancer Inst Monogr. 1998, 23: 65-71.View ArticlePubMedGoogle Scholar
- Ganem D: Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma. Curr Clin Top Infect Dis. 1998, 18: 237-251.PubMedGoogle Scholar
- Montaner S: et al, The Kaposi's sarcoma-associated herpesvirus G proteincoupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Cancer Res. 2006, 66 (1): 168-174. 10.1158/0008-5472.CAN-05-1026.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.