Author | Outcome | Follow-up | Results Comparison and reference groups | Association (95% CI) | Conclusion |
---|---|---|---|---|---|
Minkoff et al 2001 | Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL | Variable follow-up | HAART vs. no HAART, adjusted for CD4+ and initial Pap result | OR 1.4 (1.04 - 1.82), p NR | HAART has no impact on regression of SIL |
Ahdieh - Grant et al 2004 | 2 consecutive normal Pap smears after LSIL or HSIL | At least 7 years | Regression rate in person years; HAART vs. no HAART | 12.5% (9.9 - 15.1%) vs. 0%, OR/RR not reported | Unclear (incomplete reporting) |
Heard et al 1998 | Pap result: SIL | 12 months | Regression rate (%) in women on triple-drug HAART versus those not on HAART | 35% vs. 12.5%, p 0.001 | HAART promotes regression of SIL |
Heard et al 2002 | High grade CIN or HSIL and low grade CIN or LSIL or normal. | 17.7 months (median) | HAART vs. no HAART, adjusted for CD4+ | HR 1.93 (1.14 - 3.29), p 0.01 | HAART promotes regression of SIL |
Del Mistro et al 2004 | Pap result: "persistence or worsening" | 49% followed for >3 years | HAART vs. no ART | OR 0.36 (0.08-1.62), p NR | HAART has no impact on regression of SIL |
Moore et al 2002 | High grade CIN to lower grade CIN | 10 months (median) (IQR: 8 - 14) | HAART naïve versus HAART - experienced | OR 1.9 (0.28, 12.87), p 0.51 | HAART has no impact on regression of SIL |
Paramsothy et al 2009 | Pap result: Normal to ASCUS, ASCUS to LSIL, LSIL to HSIL | 2 - 2.7 years | HAART vs. no HAART | HR 1.3 (1.0 - 1.7), p >0.05 | HAART has no impact on regression of SIL |
Schuman et al 2003 | Pap result of LSIL, HSIL | 4 years (median) | HAART vs. no ART | OR 0.86 (0.50 - 1.47), p 0.57 | HAART has no impact on regression of SIL |