Table 3 Summary of studies analyzing the impact of ART on incidence of cervical disease among HIV-infected women

Ellerbrock et al 2000

Histologically confirmed SIL cytology result

3-12 month period

ARV therapy vs. no ARV therapy

RR 1.0 (0.5 - 2.0), p 0.94

ART has no impact on incidence of SIL

Schuman et al 2003

Pap result of LSIL, HSIL

4 years (median)

HAART vs. no HAART

RR 1.2 (0.49 - 2.94), p 0.7

HAART has no impact on incidence of SIL

Heard et al 2006

Pap change from normal to LSIL or HSIL

28 months (median)

HAART vs. no HAART

RR 0.7 (0.4 - 1.2), p 0.15

HAART has no impact on incidence of SIL

Sirera et al 2007

Pap change from normal to LSIL or HSIL in all women on HAART

Study period 1997 - 2005

CD4+ <200 cells/mm³ vs. >200 cells/mm³ (All participants on HAART)

OR 0.38 (0.14 - 1.01), p 0.05

HAART has no impact on incidence of SIL

Sirera et al 2008

Pap change from normal to LSIL or HSIL

Study period 1997 - 2006

HAART vs. no HAART

OR 1.84 (0.72 - 4.69), p 0.20

HAART has no impact on incidence of SIL

Soncini et al 2007

Histologically confirmed CIN

11 years

HAART vs. other NRTI or no ARV therapy, adjusted for CD4+

HR 0.3 (0.13 - 0.68), p 0.004

Only study showing HAART prevents incidence of CIN