Infectious Agents and Cancer

Table 2 Frequency and Median Years of Overall, Disease-Specific and Recurrence-free Survival by p16/p53/HPV Status

From: Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer

			Overall Survival				Disease-specific Survival				Recurrence-free Survival (N = 203)
			All Histologies N = 237		SCC N = 215		All Histologies N = 234		SCC N = 212		All Histologies N = 203		SCC N = 185
p16/p53/HPV Status	N¹	SCC (N)¹	Median	p-value²	Median	p-value²	Median	p-value²	Median	p-value²	Median	p-value²	Median	p-value²
p16+	89	77	2.3	referent	2.3	referent	2.3	referent	2.3	referent	2.3	referent	2.3	referent
p16-	148	138	1.7	0.009	1.7	0.01	1.7	0.008	1.7	0.01	1.4	0.0001	1.4	< 0.001
p53-	123	109	2.0	referent	2.0	referent	1.9	referent	1.9	referent	1.9	referent	1.9	referent
p53+	114	106	1.7	0.39	1.7	0.24	1.7	0.41	1.7	0.25	1.6	0.17	1.5	0.15
HPV-HR	66	63	2.3	referent	2.3	referent	2.3	referent	2.3	referent	2.5	referent	2.3	referent
HPV-²	171	152	1.7	0.002	1.6	0.001	1.6	0.002	1.6	0.001	1.5	0.0008	1.4	< 0.001
p16+/p53-/HPV-HR	37	36	2.3	referent	2.3	referent	2.3	referent	2.3	referent	2.7	referent	2.6	referent
p16-/p53-/HPV-HR	3	2	2.8	0.77	3.1	0.46	2.8	0.77	3.1	0.46	1.9	0.50	1.9	0.54
p16+/p53+/HPV-HR	16	15	2.8	0.93	2.8	0.93	2.8	0.93	2.8	0.93	2.7	0.48	2.5	0.48
p16-/p53+/HPV-HR	10	10	1.3	0.07	1.3	0.09	1.3	0.07	1.3	0.09	1.0	0.02	1.0	0.03
p16-/p53+/HPV-	72	69	1.6	0.004	1.6	0.006	1.6	0.003	1.6	0.006	1.4	0.0001	1.4	< 0.001
p16+/p53-/HPV-	20	14	1.2	0.01	1.1	0.07	1.2	0.01	1.1	0.07	1.2	0.008	0.9	0.05
p16-/p53-/HPV-	63	57	1.8	0.02	1.8	0.01	1.8	0.02	1.7	0.01	1.5	0.001	1.4	< 0.001
p16+/p53+/HPV-	16	12	2.4	0.47	1.3	0.22	2.4	0.47	1.3	0.22	2.7	0.68	1.9	0.35

¹Number of cases with survival data; ² p-value for differences in median years within biomarker status, ³ HPV- for all low-risk and high-risk HPV types.

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